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The Science

What Is BrainJuice?


Most people have never sat through a neurology lesson - and we don’t blame them. Luckily, no doctorate degree is needed to drink BrainJuice and experience the benefits. Even though the science behind BrainJuice is complex, it is rooted in a simple idea. Whether you want to learn just the high-level basics or nerd out over the nitty gritty, we’ve got you covered. Keep reading to discover what makes BrainJuice the perfect pick-me-up.

BrainJuice

Synapses, neurons, and gray matter, oh my! The complexity of the brain can be befuddle the best of us. But, giving the brain a little TLC is critical to our overall health, happiness, productivity, and longevity. The brain is one of the few organs you can enhance and strengthen immediately - no grueling workout required.

Think about this - if your office were on the top floor of a skyscraper, would you scale the outside of the building each morning to reach your office or would you take the elevator? It’s a no-brainer - the elevator is a safer, far more effective way to reach your destination. BrainJuice is like the nutritional elevator for your brain. Nourish your brain - elevate your life.

Failing to utilize nutrition to maximize your brain’s potential is like choosing to scale the outside of a skyscraper instead of taking the elevator. Will you get to your goal? Maybe. Does it become more dangerous and unlikely? Without a doubt.

It can be overwhelming to think how the brain works, but it is detrimental to your health, happiness, productivity, and longevity to keep ignoring it. Despite its complexity, the brain is one of the few organs you can enhance and strengthen immediately. When you feed your brain, you transform your life.

When you put good in, you get good out. Acetyl L-Carnitine, Alpha-GPC, and N-Acetyl L-Tyrosine might be hard to pronounce, but they will be even harder to live without once you experience their brain boosting effects. Check out these and the other life-changing vitamins and nutrients in BrainJuice.


Ingredients


Blueberries are rich in nutrients and antioxidants to support visual brain function and protect cells from free radicals. (2)
Organic Blueberry Extract
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GTE has 20 times more antioxidants than Vitamin C and those antioxidants protect cells from damage by free radicals. (3)
Green Tea Extract

Acai Berry, an Amazonian superfood, is jam-packed with antioxidants, omega-3 fatty acids, vitamins and other nutrients to support mental energy and acuity. (4)
Organic Acai Berry Extract

Acerola cherry is a great source of Vitamin C, which helps give your brain cells energy for that mental pick-me-up you need to get things done. (5)
Organic Acerola Cherry Extract
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Methylcobalamin, the natural form of Vitamin B12, provides clean energy without the jitters or crash. (6)
Vitamin B12
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Vitamin B6 supports dopamine production, which regulates mood and lowers stress levels. (7)
Vitamin B6
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Vitamin C is a natural antioxidant that your brain needs to produce the feel-good substances dopamine and adrenaline. It also strengthens your immune system. (8)
Vitamin C
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Used in energy production, Vitamin B5 helps you feel sharp and alert, so that you can power through the tasks at hand. (9)
Vitamin B5
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Acetyl L-Carnitine boosts physical and mental performance and feelings of wellbeing, while fighting depression, fatigue, and functional impairment associated with cancer. (10)
ACETYL L-CARNITINE
N-Acetyl L-Tyrosine
N-Acetyl L-Tyrosine helps reduce your feelings of stress, increases your mental performance, and lifts your mood, so you work happier and better. (11)
N-Acetyl L-Tyrosine
L-Theanine
L-Theanine helps you relax without feeling drowsy, which reduces stress and helps you stay focused and on task. (12)
L-Theanine
Alpha-GPC
Alpha-GPC is a powerful compound that helps you think clearer, boosts muscle power, and helps keep your brain healthy. (13)
Alpha-GPC



Level 1 - The High-Level Highlights


BrainJuice

BrainJuice all started with an idea: what does your brain need to focus? A lot of supplements focus broadly on nutrition, believing that a healthier diet alone can improve your brain function. We wanted to refine that. The foundations of BrainJuice were realized through tireless research and countless revisions. We looked at the brain, the body’s most complicated organ, and broke it down to the most basic elements. The cells in your nervous system communicate by sending messages through neurotransmitters. These control everything from your heartbeat to hunger, sensations of pain, arousal, and everything in between. Over time, your lifestyle, diet, physical activity, and age can all lead to diminished production of neurotransmitters.

The BrainPower blend in BrainJuice targets two important neurotransmitters. Acetylcholine is the neurotransmitter for focus, clarity, and memory, while the dopamine neurotransmitter controls good mood and motivation. Some pharmaceutical products provide your brain with these actual neurotransmitters. Over time, this can create a dependency on pharmaceuticals as your body decreases its own production of the neurotransmitters.

BrainJuice is different. Our nutrition-based approach feeds your brain the nutrients necessary to help replenish the building blocks needed to produce these neurotransmitters on your own. BrainJuice’s proprietary BrainPower Blend and its other active ingredients have been scientifically calculated and designed to help restore acetylcholine and dopamine in the brain, giving you a mental and mood boost in minutes.


Level 2 - A Deeper Dive

BrainJuice is based on the science of Functional Neurology - the study of which nutrients your brain needs to produce specific neurotransmitters. BrainJuice was crafted with the help of a health-conscious biochemist who studied under Dr. Datis Kharrazian, a Harvard Research fellow and one of the top functional neurologists in the world.* Our ingredients work together to replenish the nutrient building blocks your brain needs to produce two critical neurotransmitters - acetylcholine for focus, clarity, and memory, and dopamine for good mood and motivation. While other products on the market may include good-for-your-brain ingredients, the ingredients in BrainJuice specifically target the production of acetylcholine and dopamine.

Alpha-GPC and Acetyl L-Carnitine are precursors and Vitamin B5 is a cofactor in the production of acetylcholine.

  • Our Alpha-GPC is derived from non-GMO soy lecithin. This is a high-quality, absorbable form of choline with the ability to cross the blood-brain barrier. Other brain supplements use choline bitartrate, which is a cheaper, synthetic form of choline and is not highly absorbable by the body.

N-Acetyl L-Tyrosine is a precursor and Vitamin B6 is a cofactor in the production of dopamine.

  • We use methylcobalamin, the methylated form of vitamin B12. Methylcobalamin is the high-quality, absorbable form of B12 that is able to cross the blood-brain barrier. Competitors often use cyanocobalamin instead, which is cheaper, synthetic, and not easily absorbed.

BrainJuice


Level 3 - The Nerdy Nitty-Gritty

BrainJuice supports the production of acetylcholine for focus, clarity, and memory.

What exactly is acetylcholine?
Acetylcholine derives its name from its chemical compound: it is an ester of acetic acid (acetyl) and choline.10 Esters are organic compounds made by replacing the hydrogen of an acid by an alkyl or other organic group. Many naturally occurring fats and essential oils are esters of fatty acids.

In the brain, acetylcholine functions as a neurotransmitter and as a neuromodulator. The brain contains a number of cholinergic areas; that is, parts of the body that use or are affected by acetylcholine. Each of these cholinergic areas have distinct functions and play key roles in arousal, attention, memory and motivation.

Acetylcholine functions in both the central nervous system (CNS) and the peripheral nervous system (PNS). In the CNS, cholinergic projections from the basal forebrain to the cerebral cortex and hippocampus support the cognitive functions of those target areas. In the PNS, acetylcholine activates muscles and is a major neurotransmitter in the autonomic nervous system.(10)

Acetylcholine is also used by the brain for learning and encoding new memories.11 It is critical for cognition, attention, motivation, mental acuity, memory, and muscular contraction. Acetylcholine allows us to have clear thoughts and memories, as well as the ability to be attentive and focused.

Neato! How does BrainJuice help support acetylcholine production?

BrainJuice

Choline is the primary precursor to acetylcholine.

Alpha-GPC, also known as alpha-glyceryl-phopheryl-choline, or choline alphoscerate, is a natural choline compound and is the main ingredient in our BrainPower blend. Alpha-GPC is metabolized into choline and glycerophosphate primarily within the GI tract and brain.4 Not only has Alpha-GPC been shown to increase acetylcholine levels in the frontal cortex, but it has also been shown to be protective against cholinergic toxins at a 150 mg dosage1, 2 and has significant effects on cognitive function while being generally safe and well tolerated.3

Acetyl L-Carnitine, the secondary ingredient in our BrainPower blend, is an amino acid that has demonstrated the ability to increase acetylcholine levels.12

Vitamin B5, also known as pantothenic acid, is a precursor to acetyl Coenzyme A, an essential substrate for acetylcholine synthesis.15

Alpha-GPC, Acetyl L-Carnitine, and Vitamin B5 are three scientific superstars that work in conjunction to produce acetylcholine. Apha-GPC lends its choline molecules, while acetyl L-carnitine provides the acetyl molecules and joins forces with vitamin B5 to facilitate Acetyl CoA production. Choline and Acetyl CoA then combine to form acetylcholine. Alpha-GPC, Acetyl L-Carnitine, and Vitamin B5 have all been shown to absorb into the bloodstream and cross the blood-brain barrier. 13, 14, 15

While there is no FDA standard dosage for Alpha-GPC or Acetyl L-Carnitine, they are known to elevate acetylcholine levels proportionate to their dosage. The FDA daily value of Vitamin B5 is 10 mg, and BrainJuice contains 15 mg.16

BrainJuice also supports the production of dopamine for good mood and motivation.

What do I need to know about Dopamine?
Dopamine is a one of the primary neurotransmitters in the brain’s “reward system.” 5 6 7 This is the part of the brain that motivates us to take positive action by rewarding us with good feelings for doing good things for ourselves and others, including: being productive, exercising, helping others, winning at an activity we care about, and being praised by others whom we respect. The release of dopamine itself is what generates that good feeling that puts us in a good mood. 5 6 7

Groovy! How does BrainJuice support Dopamine production?
L-Tyrosine (also known as N-Acetyl L-Tyrosine) is a precursor to dopamine. The brain creates dopamine from the amino acid L-Tyrosine by first converting it into L-DOPA, then into dopamine.


BrainJuice

Vitamin B6 (also known as pyridoxal-5-phosphate) is also involved in synthesis of dopamine, and supports the conversion of L-tyrosine into dopamine. 9

While there is no FDA standard dosage for L-Tyrosine, as a precursor to dopamine, it is known to elevate dopamine levels in proportion to its dosage. The FDA minimum daily value of Vitamin B6 is 2 mg, and BrainJuice contains 10 mg. 16


Citations
  • Tayebati SK, et al. Effect of choline-containing phospholipids on brain cholinergic transporters in the rat. J Neurol Sci. (2011)
  • Lopez CM, et al. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav. (1991)
  • Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent. https://www.ncbi.nlm.nih.gov/pubmed/24156263
  • Nutrition And Traumatic Brain Injury: Improving Acute And Subacute Health Outcomes In Military Personnel - Choline. https://www.ncbi.nlm.nih.gov/books/NBK209327/
  • Dissecting components of reward: ‘liking’, ‘wanting’, and learning. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756052/
  • Dopamine. https://en.wikipedia.org/wiki/Dopamine
  • Reward system. https://en.wikipedia.org/wiki/Reward_system
  • Tyrosine. https://en.wikipedia.org/wiki/Tyrosine
  • Biochemistry, Genetics and Molecular Biology - Pyridoxal phosphate. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/pyridoxal-phosphate
  • Acetylcholine. https://en.wikipedia.org/wiki/Acetylcholine
  • The Role of Acetylcholine in Learning and Memory. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
  • Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: a review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863555/
  • Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. https://www.ncbi.nlm.nih.gov/pubmed/14595704
  • Absorption, tissue distribution and excretion of radiolabeled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. 
    https://www.ncbi.nlm.nih.gov/pubmed/3709792
  • Effects of ethanol and pantothenic acid (vitamin B5) on brain acetylcholine synthesis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854155/pdf/brjpharm00278-0079.pdf
  • Vitamin and Mineral Chart. https://www.accessdata.fda.gov/scripts/InteractiveNutritionFactsLabel/factsheets/Vitamin_and_Mineral_Chart.pdf

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